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Yes. Most modern payroll systems connect to QuickBooks Online, QuickBooks Desktop, Xero, Sage, and other accounting software, and to an HRIS, but "integrate" covers four different arrangements: payroll built into the same product, a prebuilt two-way connector, a mappable general ledger export, and a manual journal entry [1][4][6][8]. The connection most small businesses care about is the payroll-to-accounting link, where each pay run posts a journal entry that debits wage and employer-tax expense and credits net pay, tax withholdings, and deduction liabilities [1][3]. Getting it right depends less on the connector than on account mapping, because every pay item, tax, and deduction has to point at an account that already exists in your books, matched exactly [5]. On the HR side, payroll is either a module of the HRIS, in which case there is nothing to sync, or a separate system that reads employee and deduction data on a schedule, where mismatched deduction codes and un-synced new hires are the usual failure points [7].